Tuesday, June 4
nucleic acids
8:30 AM – 9:00 AM Registration (at the registration desk in Portus Congress Center)
Session Chairs: Dan Peer (NeoVac, UK) and Urh Černigoj (Sartorius BIA Separations, Slovenia)
9:00 AM – 9:35 AM Chromatography in mRNA production: from analytics to purification (Rok Sekirnik, Sartorius BIA Separations)
9:35 AM – 10:00 AM Bioproduction of messenger RNA: key benefits and challenges (Chantal Pichon, INSERM)
10:00 AM – 10:25 AM Optimization of mRNA production and purification: characterization and controlling of post-transcriptional polyadenylation and its effect on mRNA quality in vitro (Pooja Tiwari, Arnav Biotech) – Online
10:25 AM – 10:55 AM Coffee Break
Session Chairs: Sara Sousa Rosa (UCL, UK) and Salomé de Sa Magalhaes (UCL, UK)
10:55 AM – 11:20 AM Innovating and digitalising mRNA vaccine and therapeutics production processes (Zoltán Kis, University of Sheffield)
11:20 AM – 11:45 AM Manufacturing of mRNA for pre-clinical and clinical studies (Tjaša Legen, BioNTech)
11:45 AM – 12:10 PM Engineering a robust and scalable mRNA manufacturing process (Bill Grier, Omega Therapeutics)
12:10 PM – 1:10 PM Lunch in the Congress Center (provided by the organizer)
Session Chairs: Andrew Knudten (Advanced Medicine Partners, USA) and Rok Sekirnik (Sartorius BIA Separations, Slovenia)
1:10 PM – 1:45 PM Next generation lipid nanoparticles for RNA vaccines and therapeutics (Dan Peer, NeoVac)
1:45 PM – 2:10 PM LipidBrick®: An innovative cationic lipid library for efficient and tunable mRNA-LNPs (Guillaume Freund, Polyplus)
2:10 PM – 2:35 PM Engineered EVs for mRNA cargo loading and delivery (Antje Zickler, Karolinska Institutet)
2:35 PM – 3:00 PM Thermodynamic analysis of chromatography media and mRNA properties in oligo dT affinity chromatography (Connor Smith, Orbital Therapeutics)
3:00 PM – 3:30 PM Coffee Break
Session Chairs: Zoltán Kis (University of Sheffield, UK) and Sebastijan Peljhan (Sartorius BIA Separations, Slovenia)
3:30 PM – 3:55 PM All-scale continuous mRNA-LNP manufacturing (Flora Binder, Dillico)
3:55 PM – 4:10 PM YRC: Monolithic columns enable streamlined downstream processing and analytics of lipid nanoparticles (Tristan Kovačič, Sartorius BIA Separations)
4:10 PM – 4:30 PM YRC: Optimization of in vitro transcription reaction with design of experiments (Tjaša Marušič, COBIK & Jimmy Boman, Sartorius)