1.) Course Description
Lipid nanoparticle (LNP)-based biopharmaceuticals are revolutionizing nucleic acid delivery, yet they encounter challenges in manufacturing and characterization. Innovative solutions utilizing CIM (Convective Interaction Media) monolith chromatography enhance drug integrity, recovery rates, and characterization, including the entire process from plasmid DNA (pDNA) to RNA-LNP therapeutics. A groundbreaking purification method for LNPs replaces traditional techniques, significantly enhancing recovery, uniformity, and activity. PATfix platforms ensure rigorous quality monitoring and comprehensive characterization of payloads within LNPs. The novel chromatographic process using CIM delivers superior activity and uniformity of RNA-LNP particles, guaranteeing consistent product quality and efficiency, thereby supporting the development of scalable, safe and effective LNP-based therapies, such as CAR-T, CRISPR, and vaccines.
2.) Who Should Attend?
Process development scientists, analytics and LNP manufacturing team.
3.) Key Learnings
◾︎ Innovative solution for LNP purification
◾︎ Chromatography for LNPs
◾︎ PATfix LNP Switcher for LNP Analytics